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No days wasted7/1/2023 The researchers focused on the liver, Liang said, because when you take a drink, alcohol circulates through the bloodstream. Then, they assessed their livers for injury and markers of stress. To better understand what the drug does inside the body, the scientists fed 36 mice a daily diet of alcohol for two months, gradually increasing doses to 30% of their total food intake for an average of 39.4 g/kg of ethanol per day per mouse. It’s been used in China for liver ailments for 500 years, but how the substance works is unclear.ĭaryl Davies, Joshua Silva and Jing Liang, from left, worked on the study. Understanding how DHM can prevent hangovers and protect liversĭHM is derived from fruit from the Japanese raisin tree ( Hovenia dulcis), which is native to Japan, Korea and Southeast Asia and now commercially grown. Meanwhile, excessive alcohol consumption is a significant cause of chronic liver disease, accounting for nearly half of the cirrhosis-associated deaths in the United States, according to the study. There is no effective therapeutic agent for the disorder without major side effects. Globally, alcohol consumption contributes to 3 million deaths each year and is responsible for 5.1% of the global burden of disease, according to the World Health Organization. Centers for Disease Control and Prevention. About 88,000 people die of alcohol-related deaths annually - the third leading preventable cause of death in the United States, according to the U.S. In addition, the authors say the substance likely has wider applications to help people cope with binge drinking, alcoholism and liver damage.Īlcohol use disorders constitute the most common form of substance abuse. The findings support the utility of DHM as a dietary supplement to offset acute alcohol-related effects as well as long-term risks. The study appears today in Alcoholism: Clinical and Experimental Research. “We know DHM helps the body to metabolize alcohol faster, but how does it work? We found it activates a cascade of mechanisms that erase alcohol from the body very quickly,” said Jing Liang, a research professor of clinical pharmacy and the corresponding author of the study. When researchers at the USC School of Pharmacy sought to understand how it works, their investigation revealed a sequence of metabolic changes responsible not only for easing headaches but also benefitting the liver. The study focuses on dihydromyricetin (DHM), also known as ampelopsin, an over-the-counter herbal remedy. (Illustration/Philipp Franz von Siebold and Joseph Gerhard Zuccarini) Hovenia dulcis - known as the Japanese raisin tree - is the source of dihydromyricetin (DHM), which can help the body metabolize alcohol faster.
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